MGP Database

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MGP003175

Record overview

MGPD IDMGP003175
Gene ID7157
SpeciesHomo sapiens (Human)
Gene Nametumor protein p53
Gene Symbol TP53
SynonymsP53; BCC7; LFS1; TRP53;
Alternate namescellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; tumor protein 53;
Chromosome17
Map Location17p13.1
SummaryThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
OrthologsView orthologs and multiple alignments for TP53

Proteins

cellular tumor antigen p53 isoform a
Refseq ID:NP_000537
Protein GI:120407068
UniProt ID:P04637
mRNA ID:NM_000546
Length:393
RefSeq Status:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQ
KTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGN
LRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
 
cellular tumor antigen p53 isoform a
Refseq ID:NP_001119584
Protein GI:187830777
UniProt ID:P04637
mRNA ID:NM_001126112
Length:393
RefSeq Status:
Protein sequence is identical to GI:120407068 (mRNA isoform)
 
cellular tumor antigen p53 isoform b
Refseq ID:NP_001119586
Protein GI:187830855
UniProt ID:P04637
mRNA ID:NM_001126114
Length:341
RefSeq Status:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQ
KTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGN
LRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKENC
 
cellular tumor antigen p53 isoform c
Refseq ID:NP_001119585
Protein GI:187830823
UniProt ID:P04637
mRNA ID:NM_001126113
Length:346
RefSeq Status:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQ
KTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGN
LRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWCYFLINSS
 
cellular tumor antigen p53 isoform d
Refseq ID:NP_001119587
Protein GI:187830894
UniProt ID:P04637
mRNA ID:NM_001126115
Length:261
RefSeq Status:
MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTI
HYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQI
RGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
 
cellular tumor antigen p53 isoform e
Refseq ID:NP_001119588
Protein GI:187830901
UniProt ID:P04637
mRNA ID:NM_001126116
Length:209
RefSeq Status:
MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTI
HYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQD
QTSFQKENC
 
cellular tumor antigen p53 isoform f
Refseq ID:NP_001119589
Protein GI:187830909
UniProt ID:P04637
mRNA ID:NM_001126117
Length:214
RefSeq Status:
MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTI
HYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQM
LLDLRWCYFLINSS
 
cellular tumor antigen p53 isoform g
Refseq ID:NP_001119590
Protein GI:371502119
UniProt ID:P04637
mRNA ID:NM_001126118
Length:354
RefSeq Status:
MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAK
TCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCN
SSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFE
MFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
 
cellular tumor antigen p53 isoform g
Refseq ID:NP_001263690
Protein GI:454521557
UniProt ID:P04637
mRNA ID:NM_001276761
Length:354
RefSeq Status:
Protein sequence is identical to GI:371502119 (mRNA isoform)
 
cellular tumor antigen p53 isoform g
Refseq ID:NP_001263689
Protein GI:454520873
UniProt ID:P04637
mRNA ID:NM_001276760
Length:354
RefSeq Status:
Protein sequence is identical to GI:371502119 (mRNA isoform)
 
cellular tumor antigen p53 isoform h
Refseq ID:NP_001263624
Protein GI:454543597
UniProt ID:P04637
mRNA ID:NM_001276695
Length:307
RefSeq Status:
MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAK
TCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCN
SSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWC
YFLINSS
 
cellular tumor antigen p53 isoform i
Refseq ID:NP_001263625
Protein GI:454544286
UniProt ID:P04637
mRNA ID:NM_001276696
Length:302
RefSeq Status:
MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAK
TCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCN
SSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKE
NC
 
cellular tumor antigen p53 isoform j
Refseq ID:NP_001263626
Protein GI:454544715
UniProt ID:P04637
mRNA ID:NM_001276697
Length:234
RefSeq Status:
MAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLED
SSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEP
GGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
 
cellular tumor antigen p53 isoform k
Refseq ID:NP_001263627
Protein GI:454545207
UniProt ID:P04637
mRNA ID:NM_001276698
Length:182
RefSeq Status:
MAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLED
SSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKENC
 
cellular tumor antigen p53 isoform l
Refseq ID:NP_001263628
Protein GI:454545707
UniProt ID:P04637
mRNA ID:NM_001276699
Length:187
RefSeq Status:
MAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLED
SSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWCYFLINSS
 
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