MGP Database

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MGP003175

Ontology/Pathway Information

Entrez Gene ID7157
Gene Nametumor protein p53
Gene Symbol TP53
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000785 IBA:GO_CentralCchromatin
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0005783 IEA:UniProtKB-SubCellCendoplasmic reticulum
GO:0005759 IEA:UniProtKB-SubCellCmitochondrial matrix
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0000790 IDA:BHF-UCLCnuclear chromatin
GO:0016363 IDA:UniProtKBCnuclear matrix
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0016605 IDA:UniProtKBCPML body
GO:0043234 IDA:BHF-UCLCprotein complex
GO:0005657 IBA:GO_CentralCreplication fork
GO:0005524 IDA:UniProtKBFATP binding
GO:0051087 IPI:UniProtKBFchaperone binding
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0005507 IDA:UniProtKBFcopper ion binding
GO:0003684 IBA:GO_CentralFdamaged DNA binding
GO:0003677 IMP:UniProtKBFDNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0035035 IPI:UniProtKBFhistone acetyltransferase binding
GO:0035033 IEA:EnsemblFhistone deacetylase regulator activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0002039 IBA:GO_CentralFp53 binding
GO:0002020 IPI:UniProtKBFprotease binding
GO:0046982 IPI:UniProtKBFprotein heterodimerization activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0047485 IPI:UniProtKBFprotein N-terminus binding
GO:0051721 IPI:UniProtKBFprotein phosphatase 2A binding
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0030971 IPI:BHF-UCLFreceptor tyrosine kinase binding
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979 IEA:EnsemblFRNA polymerase II core promoter sequence-specific DNA binding
GO:0001085 IPI:BHF-UCLFRNA polymerase II transcription factor binding
GO:0001228 IDA:BHF-UCLFRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0008270 TAS:UniProtKBFzinc ion binding
GO:0006915 TAS:ReactomePapoptotic process
GO:0006284 TAS:UniProtKBPbase-excision repair
GO:0002326 IEA:EnsemblPB cell lineage commitment
GO:0007596 TAS:ReactomePblood coagulation
GO:0007569 IMP:UniProtKBPcell aging
GO:0007050 IMP:UniProtKBPcell cycle arrest
GO:0030154 TAS:UniProtKBPcell differentiation
GO:0008283 TAS:UniProtKBPcell proliferation
GO:0034613 IDA:UniProtKBPcellular protein localization
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0035690 IEP:UniProtKBPcellular response to drug
GO:0042149 IDA:UniProtKBPcellular response to glucose starvation
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0071479 IMP:BHF-UCLPcellular response to ionizing radiation
GO:0034644 IBA:GO_CentralPcellular response to UV
GO:0021549 IEA:EnsemblPcerebellum development
GO:0031497 IDA:UniProtKBPchromatin assembly
GO:0008340 ISS:BHF-UCLPdetermination of adult lifespan
GO:0030330 IDA:BHF-UCLPDNA damage response, signal transduction by p53 class mediator
GO:0006977 TAS:ReactomePDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 IMP:BHF-UCLPDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000733 IDA:UniProtKBPDNA strand renaturation
GO:0006302 IEA:EnsemblPdouble-strand break repair
GO:0048568 IEA:EnsemblPembryonic organ development
GO:0006983 IDA:MGIPER overload response
GO:0007369 IEA:EnsemblPgastrulation
GO:0097193 TAS:HGNCPintrinsic apoptotic signaling pathway
GO:0072332 IMP:UniProtKBPintrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771 IDA:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0071850 IEA:EnsemblPmitotic cell cycle arrest
GO:0031571 IMP:BHF-UCLPmitotic G1 DNA damage checkpoint
GO:0007275 IMP:UniProtKBPmulticellular organismal development
GO:0035264 IEA:EnsemblPmulticellular organism growth
GO:0070266 IEA:EnsemblPnecroptotic process
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0030308 IMP:UniProtKBPnegative regulation of cell growth
GO:0008285 ISS:BHF-UCLPnegative regulation of cell proliferation
GO:0008156 IEA:EnsemblPnegative regulation of DNA replication
GO:0048147 IMP:UniProtKBPnegative regulation of fibroblast proliferation
GO:0051097 TAS:UniProtKBPnegative regulation of helicase activity
GO:1901525 IEA:EnsemblPnegative regulation of macromitophagy
GO:0007406 IEA:EnsemblPnegative regulation of neuroblast proliferation
GO:2000378 IEA:EnsemblPnegative regulation of reactive oxygen species metabolic process
GO:0045892 ISS:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0030512 IEA:EnsemblPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0051402 IEA:EnsemblPneuron apoptotic process
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0006289 IMP:UniProtKBPnucleotide-excision repair
GO:0097252 IDA:UniProtKBPoligodendrocyte apoptotic process
GO:0090403 IMP:BHF-UCLPoxidative stress-induced premature senescence
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0010666 IEA:EnsemblPpositive regulation of cardiac muscle cell apoptotic process
GO:0090343 IEA:EnsemblPpositive regulation of cell aging
GO:0071158 IMP:UniProtKBPpositive regulation of cell cycle arrest
GO:0031065 IBA:GO_CentralPpositive regulation of histone deacetylation
GO:2001244 IMP:UniProtKBPpositive regulation of intrinsic apoptotic signaling pathway
GO:0035794 IEA:EnsemblPpositive regulation of mitochondrial membrane permeability
GO:0043525 IBA:GO_CentralPpositive regulation of neuron apoptotic process
GO:0050731 ISS:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461 IDA:UniProtKBPpositive regulation of protein oligomerization
GO:2000379 IMP:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0090200 IDA:UniProtKBPpositive regulation of release of cytochrome c from mitochondria
GO:0070245 ISS:BHF-UCLPpositive regulation of thymocyte apoptotic process
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006461 IDA:UniProtKBPprotein complex assembly
GO:0000060 IEA:EnsemblPprotein import into nucleus, translocation
GO:0008104 IDA:UniProtKBPprotein localization
GO:0051262 TAS:UniProtKBPprotein tetramerization
GO:0007265 IEP:BHF-UCLPRas protein signal transduction
GO:0042981 IDA:MGIPregulation of apoptotic process
GO:0046902 TAS:UniProtKBPregulation of mitochondrial membrane permeability
GO:1902108 IEA:EnsemblPregulation of mitochondrial membrane permeability involved in apoptotic process
GO:0034103 IEA:EnsemblPregulation of tissue remodeling
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0090399 IMP:BHF-UCLPreplicative senescence
GO:0046677 IEP:UniProtKBPresponse to antibiotic
GO:0010332 IMP:BHF-UCLPresponse to gamma radiation
GO:0002931 IEA:EnsemblPresponse to ischemia
GO:0009651 IEA:EnsemblPresponse to salt stress
GO:0010165 IBA:GO_CentralPresponse to X-ray
GO:0009303 IEA:EnsemblPrRNA transcription
GO:0001756 IEA:EnsemblPsomitogenesis
GO:0033077 IEA:EnsemblPT cell differentiation in thymus
GO:0002360 IEA:EnsemblPT cell lineage commitment
GO:0002309 IEA:EnsemblPT cell proliferation involved in immune response
GO:0007179 IEA:EnsemblPtransforming growth factor beta receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_697Activation of BH3-only proteins
REACT_1194Activation of NOXA and translocation to mitochondria
REACT_121Activation of PUMA and translocation to mitochondria
REACT_578Apoptosis
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_169121Formation of Senescence-Associated Heterochromatin Foci (SAHF)
REACT_2254G1/S DNA Damage Checkpoints
REACT_604Hemostasis
REACT_964Intrinsic Pathway for Apoptosis
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_118744Pre-NOTCH Expression and Processing
REACT_118568Pre-NOTCH Transcription and Translation
REACT_268456Programmed Cell Death
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction
REACT_309Stabilization of p53
REACT_346Transcriptional activation of cell cycle inhibitor p21
REACT_202Transcriptional activation of p53 responsive genes
SMP Pathway Links
SMP IDDescription
SMP00436Vinblastine Action Pathway
SMP00437Vincristine Action Pathway
SMP00438Vindesine Action Pathway
SMP00439Vinorelbine Action Pathway
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