MGP Database

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MGP003181

Record overview

MGPD IDMGP003181
Gene ID7168
SpeciesHomo sapiens (Human)
Gene Nametropomyosin 1 (alpha)
Gene Symbol TPM1
SynonymsCMH3; TMSA; CMD1Y; LVNC9; C15orf13; HTM-alpha;
Alternate namestropomyosin alpha-1 chain; alpha-tropomyosin; cardiomyopathy, hypertrophic 3; sarcomeric tropomyosin kappa;
Chromosome15
Map Location15q22.1
SummaryThis gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TPM1

Proteins

tropomyosin alpha-1 chain isoform Tpm1.12br
Refseq ID:NP_001018008
Protein GI:63252904
UniProt ID:P09493
mRNA ID:NM_001018008
Length:245
RefSeq Status:
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQK
DEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAE
TRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKLALNED
 
tropomyosin alpha-1 chain isoform Tpm1.1st
Refseq ID:NP_001018005
Protein GI:63252898
UniProt ID:P09493
mRNA ID:NM_001018005
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTV
TNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
 
tropomyosin alpha-1 chain isoform Tpm1.2st
Refseq ID:NP_001288173
Protein GI:669250879
UniProt ID:P09493
mRNA ID:NM_001301244
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTV
TNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
 
tropomyosin alpha-1 chain isoform Tpm1.3sm
Refseq ID:NP_001018020
Protein GI:63252906
UniProt ID:O15513
mRNA ID:NM_001018020
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIM
DQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
 
tropomyosin alpha-1 chain isoform Tpm1.4sm
Refseq ID:NP_001018007
Protein GI:63252902
UniProt ID:P09493
mRNA ID:NM_001018007
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTV
TNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
 
tropomyosin alpha-1 chain isoform Tpm1.5cy
Refseq ID:NP_000357
Protein GI:27597085
UniProt ID:P09493
mRNA ID:NM_000366
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIM
DQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM
 
tropomyosin alpha-1 chain isoform Tpm1.6cy
Refseq ID:NP_001018004
Protein GI:63252896
UniProt ID:O15513
mRNA ID:NM_001018004
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTV
TNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
 
tropomyosin alpha-1 chain isoform Tpm1.7cy
Refseq ID:NP_001018006
Protein GI:63252900
UniProt ID:O15513
mRNA ID:NM_001018006
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIM
DQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
 
tropomyosin alpha-1 chain isoform Tpm1.8cy
Refseq ID:NP_001288218
Protein GI:669633301
UniProt ID:B7Z722
mRNA ID:NM_001301289
Length:248
RefSeq Status:
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQK
DEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAE
TRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
 
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