MGP Database

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MGP003181

Ontology/Pathway Information

Entrez Gene ID7168
Gene Nametropomyosin 1 (alpha)
Gene Symbol TPM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0032059 IMP:BHF-UCLCbleb
GO:0005856 TAS:UniProtKBCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0031941 IEA:EnsemblCfilamentous actin
GO:0005862 TAS:ProtIncCmuscle thin filament tropomyosin
GO:0032587 IDA:BHF-UCLCruffle membrane
GO:0030017 TAS:BHF-UCLCsarcomere
GO:0001725 IDA:BHF-UCLCstress fiber
GO:0003779 TAS:BHF-UCLFactin binding
GO:0008092 IPI:UniProtKBFcytoskeletal protein binding
GO:0005200 TAS:BHF-UCLFstructural constituent of cytoskeleton
GO:0008307 TAS:ProtIncFstructural constituent of muscle
GO:0060048 IMP:BHF-UCLPcardiac muscle contraction
GO:0006928 TAS:UniProtKBPcellular component movement
GO:0034614 IEP:BHF-UCLPcellular response to reactive oxygen species
GO:0007010 TAS:BHF-UCLPcytoskeleton organization
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0006936 TAS:ReactomePmuscle contraction
GO:0030049 ISS:BHF-UCLPmuscle filament sliding
GO:0030336 ISS:BHF-UCLPnegative regulation of cell migration
GO:0032781 ISS:BHF-UCLPpositive regulation of ATPase activity
GO:0045785 ISS:BHF-UCLPpositive regulation of cell adhesion
GO:0003065 ISS:BHF-UCLPpositive regulation of heart rate by epinephrine
GO:0051496 ISS:BHF-UCLPpositive regulation of stress fiber assembly
GO:0008016 TAS:ProtIncPregulation of heart contraction
GO:0006937 TAS:ProtIncPregulation of muscle contraction
GO:0031529 ISS:BHF-UCLPruffle organization
GO:0045214 IMP:BHF-UCLPsarcomere organization
GO:0055010 IMP:BHF-UCLPventricular cardiac muscle tissue morphogenesis
GO:0042060 ISS:BHF-UCLPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_17044Muscle contraction
REACT_20558Smooth Muscle Contraction
REACT_16969Striated Muscle Contraction
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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