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MGP003199

UniProt Annotations

Entry Information

Gene Name	trio Rho guanine nucleotide exchange factor
Protein Entry	TRIO_HUMAN
UniProt ID	O75962
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O75962-1; Sequence=Displayed; Name=2; IsoId=O75962-2; Sequence=VSP_004467, VSP_004468; Note=Ref.5 (AAC34245) sequence differs from that shown due to a frameshift in position 2301. {ECO:0000305}; Name=3; IsoId=O75962-3; Sequence=VSP_023306, VSP_023307; Note=No experimental confirmation available.; Name=4; IsoId=O75962-4; Sequence=VSP_037860; Note=No experimental confirmation available.; Name=5; IsoId=O75962-5; Sequence=VSP_037861, VSP_037862; Note=No experimental confirmation available.;
Catalytic Activity	ATP + a protein = ADP + a phosphoprotein.
Domain	The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.
Function	Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
Interaction	Q9NRI5:DISC1; NbExp=3; IntAct=EBI-718519, EBI-529989;
Ptm	Phosphorylated on serine residue(s). {ECO:0000269\|PubMed:18669648, ECO:0000269\|PubMed:20068231}.
Sequence Caution	Sequence=AAC34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC34245.1; Type=Frameshift; Positions=2301; Evidence={ECO:0000305}; Sequence=AAC43042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. {ECO:0000305}.
Similarity	Contains 1 CRAL-TRIO domain. {ECO:0000255\|PROSITE- ProRule:PRU00056}.
Similarity	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
Similarity	Contains 1 protein kinase domain. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Similarity	Contains 2 DH (DBL-homology) domains. {ECO:0000255\|PROSITE-ProRule:PRU00062}.
Similarity	Contains 2 PH domains. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Similarity	Contains 2 SH3 domains. {ECO:0000255\|PROSITE- ProRule:PRU00192}.
Similarity	Contains 4 spectrin repeats. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Subunit	Interacts to form a complex with leukocyte antigen related protein.
Tissue Specificity	Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TRIOID43542ch5p15.html";