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MGP003206

Record overview

MGPD IDMGP003206
Gene ID7247
SpeciesHomo sapiens (Human)
Gene Nametranslin
Gene Symbol TSN
SynonymsC3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1;
Alternate namestranslin; component 3 of promoter of RISC; recombination hotspot associated factor; recombination hotspot-binding protein; testis brain-RNA binding protein;
Chromosome2
Map Location2q21.1
EC Number3.1.-.-
SummaryThis gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
OrthologsView orthologs and multiple alignments for TSN

Proteins

translin isoform 1
Refseq ID:NP_004613
Protein GI:4759270
UniProt ID:Q15631
mRNA ID:NM_004622
Length:228
RefSeq Status:
MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVF
LAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKY
DVKKVEEVVYDLSIRGFNKETAAACVEK
 
translin isoform 2
Refseq ID:NP_001248330
Protein GI:386869380
UniProt ID:Q15631
mRNA ID:NM_001261401
Length:148
RefSeq Status:
MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVF
LAAFVVYLETETLVTREAVTEILGIEAVCQQRDCWRLLPTPPHLHLHQ
 
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