MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003206

UniProt Annotations

Entry Information
Gene Nametranslin
Protein EntryTSN_HUMAN
UniProt IDQ15631
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15631-1; Sequence=Displayed; Name=2; IsoId=Q15631-2; Sequence=VSP_044937, VSP_044938; Note=No experimental confirmation available.;
FunctionDNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
FunctionExhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
InteractionQ14161:GIT2; NbExp=2; IntAct=EBI-1044160, EBI-1046878;
SimilarityBelongs to the translin family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11801738}. Nucleus {ECO:0000269|PubMed:11801738}.
SubunitRing-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. {ECO:0000269|PubMed:21552258}.
  logo