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MGP003233

Record overview

MGPD IDMGP003233
Gene ID7307
SpeciesHomo sapiens (Human)
Gene NameU2 small nuclear RNA auxiliary factor 1
Gene Symbol U2AF1
SynonymsRN; FP793; U2AF35; U2AFBP; RNU2AF1;
Alternate namessplicing factor U2AF 35 kDa subunit; U2 small nuclear RNA auxillary factor 1; U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit; U2 snRNP auxiliary factor small subunit; U2(RNU2) small nuclear RNA auxiliary factor binding protein; splicing factor U2AF 35kDa subunit;
Chromosome21
Map Location21q22.3
SummaryThis gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for U2AF1

Proteins

splicing factor U2AF 35 kDa subunit isoform a
Refseq ID:NP_006749
Protein GI:5803207
UniProt ID:Q01081
mRNA ID:NM_006758
Length:240
RefSeq Status:
MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSR
ERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
 
splicing factor U2AF 35 kDa subunit isoform b
Refseq ID:NP_001020374
Protein GI:68800128
UniProt ID:Q01081
mRNA ID:NM_001025203
Length:240
RefSeq Status:
MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTILIQNIYRNPQNSAQTADGSHCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSR
ERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
 
splicing factor U2AF 35 kDa subunit isoform c
Refseq ID:NP_001020375
Protein GI:68800138
UniProt ID:Q01081
mRNA ID:NM_001025204
Length:167
RefSeq Status:
MQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMH
LKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
 
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