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MGP003261

UniProt Annotations

Entry Information
Gene NameUDP-glucose ceramide glucosyltransferase
Protein EntryCEGT_HUMAN
UniProt IDQ16739
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. {ECO:0000269|PubMed:8643456}.
FunctionCatalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". {ECO:0000269|PubMed:8643456}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityFound in all tissues examined. {ECO:0000269|PubMed:8643456}.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGCG";
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