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MGP003262

UniProt Annotations

Entry Information
Gene NameUDP-glucose 6-dehydrogenase
Protein EntryUGDH_HUMAN
UniProt IDO60701
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60701-1; Sequence=Displayed; Name=2; IsoId=O60701-2; Sequence=VSP_042550; Note=No experimental confirmation available.; Name=3; IsoId=O60701-3; Sequence=VSP_046234; Note=No experimental confirmation available.;
Catalytic ActivityUDP-glucose + 2 NAD(+) + H(2)O = UDP- glucuronate + 2 NADH.
Enzyme RegulationUDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch. {ECO:0000269|PubMed:21961565}.
FunctionInvolved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
PathwayNucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
SimilarityBelongs to the UDP-glucose/GDP-mannose dehydrogenase family. {ECO:0000305}.
SubunitHomohexamer. {ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:21984906}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:9850599}.
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