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MGP003265

Record overview

MGPD IDMGP003265
Gene ID7364
SpeciesHomo sapiens (Human)
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B7
Gene Symbol UGT2B7
SynonymsUGT2B9; UDPGTH2; UDPGT2B7; UDPGT 2B9;
Alternate namesUDP-glucuronosyltransferase 2B7; 3,4-catechol estrogen specific; 3,4-catechol estrogen-specific UDPGT; UDP glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; UDP-glucuronyltransferase, family 2, beta-7; UDPGT 2B7; UDPGTh-2;
Chromosome4
Map Location4q13
EC Number2.4.1.17
SummaryThe protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for UGT2B7

Proteins

UDP-glucuronosyltransferase 2B7 precursor
Refseq ID:NP_001065
Protein GI:190194389
UniProt ID:P16662
mRNA ID:NM_001074
Length:529
RefSeq Status:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDL
PKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSE
LTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQP
DNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVC
VATVIFIVTKCCLFCFWKFARKAKKGKND
 
sig_peptide: 1..23
inference: non-experimental evidence, no additional details recorded
note: By similarity; propagated from UniProtKB/Swiss-Prot (P16662.1)
calculated_mol_wt: 2564
peptide sequence: 
MSVKWTSVILLIQLSFCFSSGNC

mat_peptide: 24..529
product: UDP-glucuronosyltransferase 2B7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P16662.1)
calculated_mol_wt: 58175
peptide sequence: 
GKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDIT
RKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFW
FEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANV
IASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSST
DLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKA
KKGKND
 
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