MGP Database

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MGP003265

UniProt Annotations

Entry Information
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B7
Protein EntryUD2B7_HUMAN
UniProt IDP16662
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. {ECO:0000269|PubMed:17442341}.
FunctionIts unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro). {ECO:0000269|PubMed:17442341}.
FunctionUDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. {ECO:0000269|PubMed:17442341}.
SimilarityBelongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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