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MGP003267

Record overview

MGPD IDMGP003267
Gene ID7366
SpeciesHomo sapiens (Human)
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B15
Gene Symbol UGT2B15
SynonymsHLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15;
Alternate namesUDP-glucuronosyltransferase 2B15; UDP glycosyltransferase 2B15; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B15; UDPGTh-3;
Chromosome4
Map Location4q13
EC Number2.4.1.17
SummaryThis gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for UGT2B15

Proteins

UDP-glucuronosyltransferase 2B15 precursor
Refseq ID:NP_001067
Protein GI:116517299
UniProt ID:P54855
mRNA ID:NM_001076
Length:530
RefSeq Status:
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYG
VSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMS
ELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQ
HDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLA
CVATVIFIITKFCLFCFRKLAKKGKKKKRD
 
sig_peptide: 1..23
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P54855.3)
calculated_mol_wt: 2601
peptide sequence: 
MSLKWTSVFLLIQLSCYFSSGSC

mat_peptide: 24..530
product: UDP-glucuronosyltransferase 2B15
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P54855.3)
calculated_mol_wt: 58454
peptide sequence: 
GKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDY
SNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDF
WFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESAN
MIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSS
RDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKK
GKKKKRD
 
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