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MGP003267

UniProt Annotations

Entry Information
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B15
Protein EntryUDB15_HUMAN
UniProt IDP54855
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
CautionPubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme. {ECO:0000305}.
FunctionUDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
SimilarityBelongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in many tissues. Present in liver, prostate and testis. {ECO:0000269|PubMed:8399210}.
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