MGP Database

MGP003269

Record overview

MGPD ID	MGP003269
Gene ID	7368
Species	Homo sapiens (Human)
Gene Name	UDP glycosyltransferase 8
Gene Symbol	UGT8
Synonyms	CGT; UGT4;
Alternate names	2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; ceramide UDP-galactosyltransferase; cerebroside synthase; uridine diphosphate glycosyltransferase 8;
Chromosome	4
Map Location	4q26
EC Number	2.4.1.45
Summary	The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Orthologs	View orthologs and multiple alignments for UGT8

Proteins

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

Refseq ID:	NP_001121646
Protein GI:	189491660
UniProt ID:	Q16880
mRNA ID:	NM_001128174
Length:	541
RefSeq Status:

MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTA
IELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVY
LISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYL
SEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLE
WKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIY
RKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK

sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 2260
peptide sequence: 
MKSYTPYFILLWSAVGIAKA

mat_peptide: 21..541
product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 59214
peptide sequence: 
AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQ
KYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI
WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYH
NGILNGKYKRNGHIKHEKKVK

sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 2260
peptide sequence: 
MKSYTPYFILLWSAVGIAKA

mat_peptide: 21..541
product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 59214
peptide sequence: 
AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQ
KYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI
WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYH
NGILNGKYKRNGHIKHEKKVK

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

Refseq ID:	NP_003351
Protein GI:	40254471
UniProt ID:	Q16880
mRNA ID:	NM_003360
Length:	541
RefSeq Status:

Protein sequence is identical to GI:189491660 (mRNA isoform)

sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 2260
peptide sequence: 
MKSYTPYFILLWSAVGIAKA

mat_peptide: 21..541
product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 59214
peptide sequence: 
AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQ
KYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI
WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYH
NGILNGKYKRNGHIKHEKKVK