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MGP Database

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MGP003269

UniProt Annotations

Entry Information

Gene Name	UDP glycosyltransferase 8
Protein Entry	CGT_HUMAN
UniProt ID	Q16880
Species	Human

Comments

Comment type	Description
Catalytic Activity	UDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine.
Function	Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
Pathway	Sphingolipid metabolism; galactosylceramide biosynthesis.
Similarity	Belongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Web Resource	Name=Functional Glycomics Gateway - GTase; Note=2- hydroxyacylsphingosine 1-beta-galactosyltransferase precursor; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_449";