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MGP003272

Record overview

MGPD IDMGP003272
Gene ID7376
SpeciesHomo sapiens (Human)
Gene Namenuclear receptor subfamily 1, group H, member 2
Gene Symbol NR1H2
SynonymsNER; UNR; LXRB; LXR-b; NER-I; RIP15;
Alternate namesoxysterols receptor LXR-beta; LX receptor beta; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; nuclear receptor NER; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor;
Chromosome19
Map Location19q13.3
SummaryThe liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
OrthologsView orthologs and multiple alignments for NR1H2

Proteins

oxysterols receptor LXR-beta isoform 1
Refseq ID:NP_009052
Protein GI:85362735
UniProt ID:P55055
mRNA ID:NM_007121
Length:461
RefSeq Status:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYN
VLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGA
SPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ
IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYV
EALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
 
oxysterols receptor LXR-beta isoform 2
Refseq ID:NP_001243576
Protein GI:375331888
UniProt ID:P55055
mRNA ID:NM_001256647
Length:364
RefSeq Status:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWGVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG
PGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGR
EDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ
PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
 
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