MGP Database

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MGP003272

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 2
Protein EntryNR1H2_HUMAN
UniProt IDP55055
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55055-1; Sequence=Displayed; Name=2; IsoId=P55055-2; Sequence=VSP_053789; Note=No experimental confirmation.;
FunctionNuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). {ECO:0000250}.
InteractionO95477:ABCA1; NbExp=2; IntAct=EBI-745354, EBI-784112; Q99750:MDFI; NbExp=3; IntAct=EBI-745354, EBI-724076;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitForms a heterodimer with RXR. {ECO:0000269|PubMed:12819202}.
Tissue SpecificityUbiquitous.
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