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MGP003273

Record overview

MGPD IDMGP003273
Gene ID7378
SpeciesHomo sapiens (Human)
Gene Nameuridine phosphorylase 1
Gene Symbol UPP1
SynonymsUP; UPP; UPASE; UDRPASE;
Alternate namesuridine phosphorylase 1; UPase 1; urdPase 1;
Chromosome7
Map Location7p12.3
EC Number2.4.2.3;
SummaryThe 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
OrthologsView orthologs and multiple alignments for UPP1

Proteins

uridine phosphorylase 1 isoform a
Refseq ID:NP_003355
Protein GI:4507839
UniProt ID:Q16831
mRNA ID:NM_003364
Length:310
RefSeq Status:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKV
GPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEF
TTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA
 
uridine phosphorylase 1 isoform a
Refseq ID:NP_001274355
Protein GI:566006139
UniProt ID:Q16831
mRNA ID:NM_001287426
Length:310
RefSeq Status:
Protein sequence is identical to GI:4507839 (mRNA isoform)
 
uridine phosphorylase 1 isoform b
Refseq ID:NP_001274357
Protein GI:566006090
UniProt ID:Q16831
mRNA ID:NM_001287428
Length:173
RefSeq Status:
MQRKLKVTSLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLE
AAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
 
uridine phosphorylase 1 isoform b
Refseq ID:NP_001274358
Protein GI:566006152
UniProt ID:Q16831
mRNA ID:NM_001287429
Length:173
RefSeq Status:
Protein sequence is identical to GI:566006090 (mRNA isoform)
 
uridine phosphorylase 1 isoform b
Refseq ID:NP_001274359
Protein GI:566006146
UniProt ID:Q16831
mRNA ID:NM_001287430
Length:173
RefSeq Status:
Protein sequence is identical to GI:566006090 (mRNA isoform)
 
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