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MGP003273

UniProt Annotations

Entry Information
Gene Nameuridine phosphorylase 1
Protein EntryUPP1_HUMAN
UniProt IDQ16831
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16831-1; Sequence=Displayed; Name=2; Synonyms=Truncated; IsoId=Q16831-2; Sequence=VSP_001279, VSP_001280; Note=Inactive.;
Catalytic ActivityUridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
FunctionCatalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
InductionBy vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma.
PathwayPyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
SimilarityBelongs to the PNP/UDP phosphorylase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:19291308, ECO:0000269|PubMed:20856879}.
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