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MGP003291

UniProt Annotations

Entry Information

Gene Name	voltage-dependent anion channel 1
Protein Entry	VDAC1_HUMAN
UniProt ID	P21796
Species	Human

Comments

Comment type	Description
Domain	Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
Function	Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269\|PubMed:11845315, ECO:0000269\|PubMed:15033708, ECO:0000269\|PubMed:18755977, ECO:0000269\|PubMed:20230784}.
Interaction	P19367:HK1; NbExp=2; IntAct=EBI-354158, EBI-713162;
Ptm	Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. {ECO:0000269\|PubMed:20230784}.
Similarity	Belongs to the eukaryotic mitochondrial porin family. {ECO:0000305}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269\|PubMed:7539795}. Cell membrane {ECO:0000269\|PubMed:7539795}.
Subunit	Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with BOP/C22orf29 (via BH3 domain). Interacts with influenza A virus PB1-F2 protein. Interacts with HK1. The HK1-VDAC1 complex interacts with ATF2 (By similarity). {ECO:0000250}.
Tissue Specificity	Heart, liver and skeletal muscle.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/VDAC1ID50902ch5q31.html";