MGP Database

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MGP003293

Ontology/Pathway Information

Entrez Gene ID7422
Gene Namevascular endothelial growth factor A
Gene Symbol VEGFA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0016020 IEA:InterProCmembrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005578 NAS:UniProtKBCproteinaceous extracellular matrix
GO:0030141 IDA:UniProtKBCsecretory granule
GO:0042056 IDA:UniProtKBFchemoattractant activity
GO:0005125 IDA:BHF-UCLFcytokine activity
GO:0050840 IC:BHF-UCLFextracellular matrix binding
GO:0001968 IDA:BHF-UCLFfibronectin binding
GO:0008083 IDA:BHF-UCLFgrowth factor activity
GO:0008201 IDA:UniProtKBFheparin binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0038191 IPI:BHF-UCLFneuropilin binding
GO:0005161 IPI:BHF-UCLFplatelet-derived growth factor receptor binding
GO:0046982 IDA:MGIFprotein heterodimerization activity
GO:0042803 ISS:BHF-UCLFprotein homodimerization activity
GO:0048018 IPI:BHF-UCLFreceptor agonist activity
GO:0043183 IPI:BHF-UCLFvascular endothelial growth factor receptor 1 binding
GO:0043184 IPI:BHF-UCLFvascular endothelial growth factor receptor 2 binding
GO:0005172 IPI:UniProtKBFvascular endothelial growth factor receptor binding
GO:0032147 IDA:BHF-UCLPactivation of protein kinase activity
GO:0001525 IDA:UniProtKBPangiogenesis
GO:0048844 ISS:BHF-UCLPartery morphogenesis
GO:0002575 IDA:UniProtKBPbasophil chemotaxis
GO:0007596 TAS:ReactomePblood coagulation
GO:0048754 ISS:BHF-UCLPbranching morphogenesis of an epithelial tube
GO:0048593 ISS:BHF-UCLPcamera-type eye morphogenesis
GO:0048739 ISS:BHF-UCLPcardiac muscle fiber development
GO:0060948 ISS:BHF-UCLPcardiac vascular smooth muscle cell development
GO:0048469 ISS:BHF-UCLPcell maturation
GO:0002042 IDA:BHF-UCLPcell migration involved in sprouting angiogenesis
GO:0071456 IDA:MGIPcellular response to hypoxia
GO:0035924 IDA:BHF-UCLPcellular response to vascular endothelial growth factor stimulus
GO:0071679 ISS:BHF-UCLPcommissural neuron axon guidance
GO:0060982 ISS:BHF-UCLPcoronary artery morphogenesis
GO:0003169 ISS:BHF-UCLPcoronary vein morphogenesis
GO:0071542 ISS:BHF-UCLPdopaminergic neuron differentiation
GO:0035767 IDA:BHF-UCLPendothelial cell chemotaxis
GO:0030855 ISS:BHF-UCLPepithelial cell differentiation
GO:0042462 ISS:BHF-UCLPeye photoreceptor cell development
GO:0040007 ISS:BHF-UCLPgrowth
GO:0003007 ISS:BHF-UCLPheart morphogenesis
GO:0050930 IDA:UniProtKBPinduction of positive chemotaxis
GO:0001701 ISS:BHF-UCLPin utero embryonic development
GO:0001822 ISS:BHF-UCLPkidney development
GO:0007595 ISS:BHF-UCLPlactation
GO:0030324 ISS:BHF-UCLPlung development
GO:0036303 ISS:BHF-UCLPlymph vessel morphogenesis
GO:0030225 IDA:DFLATPmacrophage differentiation
GO:0060749 ISS:BHF-UCLPmammary gland alveolus development
GO:0007498 ISS:BHF-UCLPmesoderm development
GO:0030224 IDA:DFLATPmonocyte differentiation
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0043154 IDA:UniProtKBPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0007399 TAS:UniProtKBPnervous system development
GO:0003151 ISS:BHF-UCLPoutflow tract morphogenesis
GO:0001541 ISS:BHF-UCLPovarian follicle development
GO:0001569 ISS:BHF-UCLPpatterning of blood vessels
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0050918 IDA:BHF-UCLPpositive chemotaxis
GO:0045766 IDA:UniProtKBPpositive regulation of angiogenesis
GO:0048842 ISS:BHF-UCLPpositive regulation of axon extension involved in axon guidance
GO:0043536 IDA:BHF-UCLPpositive regulation of blood vessel endothelial cell migration
GO:0090190 ISS:BHF-UCLPpositive regulation of branching involved in ureteric bud morphogenesis
GO:0045785 IDA:UniProtKBPpositive regulation of cell adhesion
GO:0051781 IEA:UniProtKB-KWPpositive regulation of cell division
GO:0030335 IDA:BHF-UCLPpositive regulation of cell migration
GO:0090050 IDA:BHF-UCLPpositive regulation of cell migration involved in sprouting angiogenesis
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0038091 IDA:BHF-UCLPpositive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0051272 IDA:BHF-UCLPpositive regulation of cellular component movement
GO:0032793 IDA:BHF-UCLPpositive regulation of CREB transcription factor activity
GO:0038033 IDA:BHF-UCLPpositive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0010595 IDA:UniProtKBPpositive regulation of endothelial cell migration
GO:0001938 IDA:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0050679 ISS:BHF-UCLPpositive regulation of epithelial cell proliferation
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0051894 IDA:UniProtKBPpositive regulation of focal adhesion assembly
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:1901727 IDA:BHF-UCLPpositive regulation of histone deacetylase activity
GO:0002687 TAS:BHF-UCLPpositive regulation of leukocyte migration
GO:0043406 IDA:BHF-UCLPpositive regulation of MAP kinase activity
GO:0060754 IDA:UniProtKBPpositive regulation of mast cell chemotaxis
GO:0002053 ISS:BHF-UCLPpositive regulation of mesenchymal cell proliferation
GO:0002052 ISS:BHF-UCLPpositive regulation of neuroblast proliferation
GO:1900745 IDA:UniProtKBPpositive regulation of p38MAPK cascade
GO:0033138 IDA:BHF-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:1900086 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine autophosphorylation
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050927 IDA:BHF-UCLPpositive regulation of positive chemotaxis
GO:0031954 IDA:BHF-UCLPpositive regulation of protein autophosphorylation
GO:0031334 IDA:UniProtKBPpositive regulation of protein complex assembly
GO:0090037 IDA:BHF-UCLPpositive regulation of protein kinase C signaling
GO:1903572 IDA:BHF-UCLPpositive regulation of protein kinase D signaling
GO:1902966 IDA:BHF-UCLPpositive regulation of protein localization to early endosome
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0002092 IDA:BHF-UCLPpositive regulation of receptor internalization
GO:1902336 ISS:BHF-UCLPpositive regulation of retinal ganglion cell axon guidance
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0061419 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0030949 IDA:BHF-UCLPpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0043117 IDA:UniProtKBPpositive regulation of vascular permeability
GO:0031077 ISS:BHF-UCLPpost-embryonic camera-type eye development
GO:0060319 ISS:BHF-UCLPprimitive erythrocyte differentiation
GO:0008360 IDA:BHF-UCLPregulation of cell shape
GO:0030823 IDA:MGIPregulation of cGMP metabolic process
GO:0090259 ISS:BHF-UCLPregulation of retinal ganglion cell axon guidance
GO:0006357 IMP:BHF-UCLPregulation of transcription from RNA polymerase II promoter
GO:0061418 TAS:ReactomePregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0001666 IDA:UniProtKBPresponse to hypoxia
GO:0043129 ISS:BHF-UCLPsurfactant homeostasis
GO:0035148 IDA:UniProtKBPtube formation
GO:0048010 IDA:BHF-UCLPvascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA:BHF-UCLPvascular endothelial growth factor signaling pathway
GO:0001570 TAS:UniProtKBPvasculogenesis
GO:0038190 ISS:BHF-UCLPVEGF-activated neuropilin signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_121311Cellular response to hypoxia
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_121092Regulation of gene expression by Hypoxia-inducible Factor
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by oxygen
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_12583VEGF binds to VEGFR leading to receptor dimerization
REACT_12380VEGF ligand-receptor interactions
SMP Pathway Links
SMP IDDescription
SMP00420Bevacizumab Action Pathway
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