MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003297

Record overview

MGPD IDMGP003297
Gene ID7430
SpeciesHomo sapiens (Human)
Gene Nameezrin
Gene Symbol EZR
SynonymsCVL; CVIL; VIL2; HEL-S-105;
Alternate namesezrin; cytovillin 2; epididymis secretory protein Li 105; p81; villin 2 (ezrin); villin-2;
Chromosome6
Map Location6q25.3
SummaryThe cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EZR

Proteins

ezrin
Refseq ID:NP_001104547
Protein GI:161702986
UniProt ID:P15311
mRNA ID:NM_001111077
Length:586
RefSeq Status:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQK
LFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEM
YGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAK
EELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYS
AELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
 
ezrin
Refseq ID:NP_003370
Protein GI:21614499
UniProt ID:P15311
mRNA ID:NM_003379
Length:586
RefSeq Status:
Protein sequence is identical to GI:161702986 (mRNA isoform)
 
  logo