MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003297

UniProt Annotations

Entry Information
Gene Nameezrin
Protein EntryEZRI_HUMAN
UniProt IDP15311
SpeciesHuman
Comments
Comment typeDescription
Developmental StageVery strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain. {ECO:0000269|PubMed:15797715}.
Enzyme RegulationA head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000250}.
FunctionProbably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
InteractionP07384:CAPN1; NbExp=2; IntAct=EBI-1056902, EBI-1542113; P07332:FES; NbExp=8; IntAct=EBI-1056902, EBI-1055635; Q00987:MDM2; NbExp=3; IntAct=EBI-1056902, EBI-389668; Q8IZE3:SCYL3; NbExp=4; IntAct=EBI-1056902, EBI-1380680;
PtmPhosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAA61278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB82418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 FERM domain. {ECO:0000255|PROSITE- ProRule:PRU00084}.
Subcellular LocationApical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.
SubunitInteracts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites. {ECO:0000250, ECO:0000269|PubMed:12651155, ECO:0000269|PubMed:12808036, ECO:0000269|PubMed:15498789, ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:9314537}.
Tissue SpecificityExpressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
  logo