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MGP003305

UniProt Annotations

Entry Information
Gene Namevitronectin
Protein EntryVTNC_HUMAN
UniProt IDP04004
SpeciesHuman
Comments
Comment typeDescription
DomainThe SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
FunctionSomatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
FunctionVitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
InteractionQ07021:C1QBP; NbExp=8; IntAct=EBI-1036653, EBI-347528;
PtmIt has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
PtmN- and O-glycosylated. {ECO:0000250}.
PtmPhosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. {ECO:0000269|PubMed:9733784}.
PtmPhosphorylation sites are present in the extracellular medium.
PtmSulfated on 2 tyrosine residues. {ECO:0000269|PubMed:17558413, ECO:0000269|PubMed:2479556}.
SimilarityContains 1 SMB (somatomedin-B) domain. {ECO:0000305}.
SimilarityContains 4 hemopexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space.
SubunitExists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP. {ECO:0000269|PubMed:12808446, ECO:0000269|PubMed:1704366, ECO:0000269|PubMed:1709100, ECO:0000269|PubMed:7522053, ECO:0000269|PubMed:8900153}.
Tissue SpecificityPlasma.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/vtn/";
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