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MGP003307

Record overview

MGPD IDMGP003307
Gene ID7453
SpeciesHomo sapiens (Human)
Gene Nametryptophanyl-tRNA synthetase
Gene Symbol WARS
SynonymsIFI53; IFP53; GAMMA-2;
Alternate namestryptophan--tRNA ligase, cytoplasmic; hWRS; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic;
Chromosome14
Map Location14q32.31
EC Number6.1.1.2
SummaryAminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for WARS

Proteins

tryptophan--tRNA ligase, cytoplasmic isoform a
Refseq ID:NP_004175
Protein GI:47419914
UniProt ID:P23381
mRNA ID:NM_004184
Length:471
RefSeq Status:
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDY
DKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK
YLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR
TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSF
MYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
 
tryptophan--tRNA ligase, cytoplasmic isoform a
Refseq ID:NP_776049
Protein GI:47419916
UniProt ID:P23381
mRNA ID:NM_173701
Length:471
RefSeq Status:
Protein sequence is identical to GI:47419914 (mRNA isoform)
 
tryptophan--tRNA ligase, cytoplasmic isoform b
Refseq ID:NP_998810
Protein GI:47419918
UniProt ID:P23381
mRNA ID:NM_213645
Length:430
RefSeq Status:
MLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHR
DMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYM
GMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFP
ALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPL
IAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
 
tryptophan--tRNA ligase, cytoplasmic isoform b
Refseq ID:NP_998811
Protein GI:47419920
UniProt ID:P23381
mRNA ID:NM_213646
Length:430
RefSeq Status:
Protein sequence is identical to GI:47419918 (mRNA isoform)
 
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