MGP Database

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MGP003307

UniProt Annotations

Entry Information
Gene Nametryptophanyl-tRNA synthetase
Protein EntrySYWC_HUMAN
UniProt IDP23381
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P23381-1; Sequence=Displayed; Name=2; Synonyms=mini TrpRS; IsoId=P23381-2; Sequence=VSP_038221;
Catalytic ActivityATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
FunctionIsoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:14630953}.
InductionBy IFNG/IFN-gamma. {ECO:0000269|PubMed:8496617}.
PtmProteolytic cleavage generates 2 forms; T1-TrpRS and T2- TrpRS. {ECO:0000269|PubMed:11773626}.
SimilarityBelongs to the class-I aminoacyl-tRNA synthetase family. {ECO:0000305}.
SimilarityContains 1 WHEP-TRS domain. {ECO:0000255|PROSITE- ProRule:PRU00531}.
Subcellular LocationCytoplasm.
SubunitHomodimer. Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2.
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