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MGP003343

UniProt Annotations

Entry Information
Gene NameZFP36 ring finger protein
Protein EntryTTP_HUMAN
UniProt IDP26651
SpeciesHuman
Comments
Comment typeDescription
FunctionmRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:23644599}.
InductionBy stimulation with various mitogens.
InteractionQ9NPI6:DCP1A; NbExp=2; IntAct=EBI-374248, EBI-374238; Q96F86:EDC3; NbExp=2; IntAct=EBI-374248, EBI-997311;
PtmPhosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation. {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:16262601, ECO:0000269|PubMed:18669648}.
SimilarityContains 2 C3H1-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00723}.
Subcellular LocationNucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
SubunitInteracts (via C-terminus) with CNOT1. {ECO:0000269|PubMed:23644599}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/zfp36/";
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