MGP Database

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MGP003382

Ontology/Pathway Information

Entrez Gene ID7706
Gene Nametripartite motif containing 25
Gene Symbol TRIM25
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 IDA:HPACnucleoplasm
GO:0016881 IEA:UniProtKB-ECFacid-amino acid ligase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0051607 IEA:UniProtKB-KWPdefense response to virus
GO:0045087 IDA:UniProtKBPinnate immune response
GO:0032480 TAS:ReactomePnegative regulation of type I interferon production
GO:0046597 IEA:EnsemblPnegative regulation of viral entry into host cell
GO:1902187 IEA:EnsemblPnegative regulation of viral release from host cell
GO:0043123 IDA:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092 IMP:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0051091 IMP:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0016567 IEA:UniProtKB-UniPathwayPprotein ubiquitination
GO:0046596 IDA:UniProtKBPregulation of viral entry into host cell
GO:1902186 IMP:UniProtKBPregulation of viral release from host cell
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0033280 IEA:EnsemblPresponse to vitamin D
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_115831ISG15 antiviral mechanism
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25026TRAF3-dependent IRF activation pathway
REACT_24938TRAF6 mediated IRF7 activation
REACT_24969TRAF6 mediated NF-kB activation
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