MGP Database

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MGP003419

UniProt Annotations

Entry Information
Gene Nameinterleukin 1 receptor, type II
Protein EntryIL1R2_HUMAN
UniProt IDP27930
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P27930-1; Sequence=Displayed; Name=Short; IsoId=P27930-2; Sequence=VSP_042222;
FunctionNon-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.
PtmA soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. {ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9395521}.
SimilarityBelongs to the interleukin-1 receptor family. {ECO:0000305}.
SimilarityContains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationIsoform Long: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform Short: Secreted {ECO:0000269|PubMed:8702856}.
SubunitAssociates with IL1RAP to form a non-signaling interleukin-1 receptor complex. {ECO:0000269|PubMed:20802483}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1r2/";
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