MGP Database

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MGP003421

Ontology/Pathway Information

Entrez Gene ID7855
Gene Namefrizzled class receptor 5
Gene Symbol FZD5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0005769 IEA:EnsemblCearly endosome
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0016021 IBA:GO_CentralCintegral component of membrane
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005923 IEA:EnsemblCtight junction
GO:0004930 IBA:GO_CentralFG-protein coupled receptor activity
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0042813 IC:BHF-UCLFWnt-activated receptor activity
GO:0017147 IPI:UniProtKBFWnt-protein binding
GO:0001525 IEA:EnsemblPangiogenesis
GO:0008595 IDA:BHF-UCLPanterior/posterior axis specification, embryo
GO:0060561 IEA:EnsemblPapoptotic process involved in morphogenesis
GO:0060670 IEA:EnsemblPbranching involved in labyrinthine layer morphogenesis
GO:0060070 IDA:BHF-UCLPcanonical Wnt signaling pathway
GO:0048469 IEA:EnsemblPcell maturation
GO:0071219 IDA:BHF-UCLPcellular response to molecule of bacterial origin
GO:0060718 IEA:EnsemblPchorionic trophoblast cell differentiation
GO:0000578 IDA:BHF-UCLPembryonic axis specification
GO:0031076 IEA:EnsemblPembryonic camera-type eye development
GO:0060716 IEA:EnsemblPlabyrinthine layer blood vessel development
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0030182 ISS:UniProtKBPneuron differentiation
GO:0035567 IBA:GO_CentralPnon-canonical Wnt signaling pathway
GO:0032729 IMP:BHF-UCLPpositive regulation of interferon-gamma production
GO:0043507 IEA:EnsemblPpositive regulation of JUN kinase activity
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0031077 IEA:EnsemblPpost-embryonic camera-type eye development
GO:0060828 IEA:EnsemblPregulation of canonical Wnt signaling pathway
GO:1901382 IEA:EnsemblPregulation of chorionic trophoblast cell proliferation
GO:2000810 IEA:EnsemblPregulation of tight junction assembly
GO:0060061 IDA:BHF-UCLPSpemann organizer formation
GO:0060715 IEA:EnsemblPsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0033077 IEA:EnsemblPT cell differentiation in thymus
GO:0044332 IDA:BHF-UCLPWnt signaling pathway involved in dorsal/ventral axis specification
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264478Asymmetric localization of PCP proteins
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_18372Class B/2 (Secretin family receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264199PCP/CE pathway
REACT_264580regulation of FZD by ubiquitination
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264533WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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