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MGP003421

UniProt Annotations

Entry Information
Gene Namefrizzled class receptor 5
Protein EntryFZD5_HUMAN
UniProt IDQ13467
SpeciesHuman
Comments
Comment typeDescription
DomainLys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.
DomainThe FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
DomainThe PDZ-binding motif mediates interaction with GOPC. {ECO:0000250}.
FunctionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269|PubMed:10097073}.
InteractionQ6P3W7:SCYL2; NbExp=4; IntAct=EBI-3913027, EBI-1046810;
PtmUbiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.
SimilarityBelongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.
SimilarityContains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE- ProRule:PRU00090}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.
SubunitInteracts with GOPC. {ECO:0000250}.
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