MGP Database

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MGP003454

Record overview

MGPD IDMGP003454
Gene ID8091
SpeciesHomo sapiens (Human)
Gene Namehigh mobility group AT-hook 2
Gene Symbol HMGA2
SynonymsBABL; LIPO; HMGIC; HMGI-C; STQTL9;
Alternate nameshigh mobility group protein HMGI-C; High-mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C;
Chromosome12
Map Location12q15
SummaryThis gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HMGA2

Proteins

high mobility group protein HMGI-C isoform a
Refseq ID:NP_003474
Protein GI:4504431
UniProt ID:P52926
mRNA ID:NM_003483
Length:109
RefSeq Status:
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEET
SSQESAEED
 
high mobility group protein HMGI-C isoform b
Refseq ID:NP_003475
Protein GI:62912482
UniProt ID:P52926
mRNA ID:NM_003484
Length:106
RefSeq Status:
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDNLLPRTSSKKKTSLGN
STKRSH
 
high mobility group protein HMGI-C isoform c
Refseq ID:NP_001287847
Protein GI:665506020
UniProt ID:F5H2A4
mRNA ID:NM_001300918
Length:118
RefSeq Status:
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQVNVALP
GKDHPGNLIYLLFSKNAT
 
high mobility group protein HMGI-C isoform d
Refseq ID:NP_001287848
Protein GI:665506022
UniProt ID:Q1M183
mRNA ID:NM_001300919
Length:147
RefSeq Status:
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPR
FKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVSPCWPGWSRTPDLR
 
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