MGP Database

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MGP003454

Ontology/Pathway Information

Entrez Gene ID8091
Gene Namehigh mobility group AT-hook 2
Gene Symbol HMGA2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000228 ISS:UniProtKBCnuclear chromosome
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0032993 IDA:UniProtKBCprotein-DNA complex
GO:0035985 IDA:UniProtKBCsenescence-associated heterochromatin focus
GO:0071141 IDA:UniProtKBCSMAD protein complex
GO:0051575 IDA:UniProtKBF5'-deoxyribose-5-phosphate lyase activity
GO:0003680 IDA:UniProtKBFAT DNA binding
GO:0070742 IMP:UniProtKBFC2H2 zinc finger domain binding
GO:0035497 IDA:UniProtKBFcAMP response element binding
GO:0001047 IDA:UniProtKBFcore promoter binding
GO:0003906 IDA:UniProtKBFDNA-(apurinic or apyrimidinic site) lyase activity
GO:0003677 NAS:UniProtKBFDNA binding
GO:0008301 IDA:UniProtKBFDNA binding, bending
GO:0004677 IDA:UniProtKBFDNA-dependent protein kinase activity
GO:0035501 IDA:UniProtKBFMH1 domain binding
GO:0035500 IDA:UniProtKBFMH2 domain binding
GO:0031492 IDA:UniProtKBFnucleosomal DNA binding
GO:0000975 IDA:UniProtKBFregulatory region DNA binding
GO:0001078 IDA:UniProtKBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001077 IDA:UniProtKBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0046332 IPI:UniProtKBFSMAD binding
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0006284 IDA:UniProtKBPbase-excision repair
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0002062 IDA:UniProtKBPchondrocyte differentiation
GO:0035988 IDA:UniProtKBPchondrocyte proliferation
GO:0006325 TAS:UniProtKBPchromatin organization
GO:0031052 IDA:UniProtKBPchromosome breakage
GO:0030261 IEA:UniProtKB-KWPchromosome condensation
GO:0000737 IDA:GOCPDNA catabolic process, endonucleolytic
GO:0042769 IDA:UniProtKBPDNA damage response, detection of DNA damage
GO:0035987 IMP:UniProtKBPendodermal cell differentiation
GO:0001837 IMP:UniProtKBPepithelial to mesenchymal transition
GO:0045444 IMP:UniProtKBPfat cell differentiation
GO:0031507 IDA:UniProtKBPheterochromatin assembly
GO:0035978 IDA:UniProtKBPhistone H2A-S139 phosphorylation
GO:0048762 IMP:UniProtKBPmesenchymal cell differentiation
GO:0048333 IMP:UniProtKBPmesodermal cell differentiation
GO:0003131 IMP:UniProtKBPmesodermal-endodermal cell signaling
GO:0007095 IDA:UniProtKBPmitotic G2 DNA damage checkpoint
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0043922 IDA:UniProtKBPnegative regulation by host of viral transcription
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0043392 IDA:UniProtKBPnegative regulation of DNA binding
GO:2001033 IDA:UniProtKBPnegative regulation of double-strand break repair via nonhomologous end joining
GO:0045869 IDA:UniProtKBPnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0090402 IDA:UniProtKBPoncogene-induced cell senescence
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0071158 IDA:UniProtKBPpositive regulation of cell cycle arrest
GO:2000685 IDA:UniProtKBPpositive regulation of cellular response to X-ray
GO:2000774 IMP:UniProtKBPpositive regulation of cellular senescence
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:2001022 IDA:UniProtKBPpositive regulation of response to DNA damage stimulus
GO:2000648 IDA:UniProtKBPpositive regulation of stem cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:2000679 IDA:UniProtKBPpositive regulation of transcription regulatory region DNA binding
GO:0010564 IDA:UniProtKBPregulation of cell cycle process
GO:2001038 IDA:UniProtKBPregulation of cellular response to drug
GO:0040008 IEA:UniProtKB-KWPregulation of growth
GO:2000036 IMP:UniProtKBPregulation of stem cell maintenance
GO:0006355 IMP:UniProtKBPregulation of transcription, DNA-templated
GO:0009615 IEP:UniProtKBPresponse to virus
GO:0035986 IDA:UniProtKBPsenescence-associated heterochromatin focus assembly
GO:0048863 IEP:UniProtKBPstem cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_169121Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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