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MGP003485

UniProt Annotations

Entry Information
Gene Namecell division cycle 45
Protein EntryCDC45_HUMAN
UniProt IDO75419
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75419-1; Sequence=Displayed; Name=2; IsoId=O75419-2; Sequence=VSP_043129; Note=No experimental confirmation available.; Name=3; IsoId=O75419-3; Sequence=VSP_045411; Note=No experimental confirmation available.;
Developmental StageTranscript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.
FunctionRequired for initiation of chromosomal DNA replication.
InteractionP38936:CDKN1A; NbExp=2; IntAct=EBI-374969, EBI-375077; Q9HAW4:CLSPN; NbExp=4; IntAct=EBI-374969, EBI-1369377; P15927:RPA2; NbExp=4; IntAct=EBI-374969, EBI-621404; Q92547:TOPBP1; NbExp=6; IntAct=EBI-374969, EBI-308302;
SimilarityBelongs to the CDC45 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus.
SubunitAssociated with ORC2.
Tissue SpecificityWidely expressed, highest levels are found in adult testis and thymus and in fetal liver.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc45l/";
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