MGP Database

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MGP003544

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group X
Protein EntryPA2GX_HUMAN
UniProt IDO15496
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:12161451}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:12161451};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityFound in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.
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