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MGP003582

Record overview

MGPD IDMGP003582
Gene ID8520
SpeciesHomo sapiens (Human)
Gene Namehistone acetyltransferase 1
Gene Symbol HAT1
SynonymsKAT1;
Alternate nameshistone acetyltransferase type B catalytic subunit;
Chromosome2
Map Location2q31.2-q33.1
EC Number2.3.1.48
SummaryThe protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
OrthologsView orthologs and multiple alignments for HAT1

Proteins

histone acetyltransferase type B catalytic subunit
Refseq ID:NP_003633
Protein GI:4504341
UniProt ID:O14929
mRNA ID:NM_003642
Length:419
RefSeq Status:
MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFD
CVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWH
YFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCF
SREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEE
SFQELVEDYRRVIERLAQE
 
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