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MGP003582

UniProt Annotations

Entry Information
Gene Namehistone acetyltransferase 1
Protein EntryHAT1_HUMAN
UniProt IDO14929
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A; Synonyms=a, Nuclear; IsoId=O14929-1; Sequence=Displayed; Name=B; Synonyms=b; IsoId=O14929-2; Sequence=VSP_041129;
Biophysicochemical PropertiesKinetic parameters: KM=6.68 uM for acetyl-CoA {ECO:0000269|PubMed:22615379}; Note=kcat is 4.14 (sec-1) for acetyl-CoA. {ECO:0000269|PubMed:22615379};
Catalytic ActivityAcetyl-CoA + [histone] = CoA + acetyl- [histone]. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.
Developmental StageHighly expressed in mitotic cells (at protein level). {ECO:0000269|PubMed:20148353}.
FunctionAcetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.
InductionUp-regulated by estrogen. {ECO:0000269|PubMed:12841681}.
InteractionP62805:HIST2H4B; NbExp=4; IntAct=EBI-2339359, EBI-302023; P12520:vpr (xeno); NbExp=3; IntAct=EBI-2339359, EBI-6164519;
Sequence CautionSequence=AAH18682.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the HAT1 family. {ECO:0000305}.
Subcellular LocationIsoform A: Nucleus matrix.
Subcellular LocationIsoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
SubunitCatalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes. {ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.
Web ResourceName=Wikipedia; Note=Histone acetyltransferase entry; URL="http://en.wikipedia.org/wiki/Histone_acetyltransferase";
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