MGP Database

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MGP003596

Ontology/Pathway Information

Entrez Gene ID8549
Gene Nameleucine-rich repeat containing G protein-coupled receptor 5
Gene Symbol LGR5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0032588 IDA:UniProtKBCtrans-Golgi network membrane
GO:0004930 TAS:ProtIncFG-protein coupled receptor activity
GO:0004888 IDA:UniProtKBFtransmembrane signaling receptor activity
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0048839 IEA:EnsemblPinner ear development
GO:0090263 IDA:UniProtKBPpositive regulation of canonical Wnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264580regulation of FZD by ubiquitination
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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