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MGP003596

UniProt Annotations

Entry Information
Gene Nameleucine-rich repeat containing G protein-coupled receptor 5
Protein EntryLGR5_HUMAN
UniProt IDO75473
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75473-1; Sequence=Displayed; Name=2; IsoId=O75473-2; Sequence=VSP_037746; Name=3; IsoId=O75473-3; Sequence=VSP_054782;
FunctionReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.
MiscellaneousLGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium. {ECO:0000305|PubMed:19030762}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
SimilarityContains 16 LRR (leucine-rich) repeats. {ECO:0000305}.
SimilarityContains 1 LRRNT domain. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
SubunitIdentified in a complex composed of RNF43, LGR5 and RSPO1. {ECO:0000269|PubMed:23756651, ECO:0000269|PubMed:23809763}.
Tissue SpecificityExpressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269|PubMed:12601349, ECO:0000269|PubMed:16575208, ECO:0000269|PubMed:19030762}.
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