MGP Database

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MGP003618

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2A
Protein EntryLPP1_HUMAN
UniProt IDO14494
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Alpha-1, hLPP1, PAP2-a1; IsoId=O14494-1; Sequence=Displayed; Name=2; Synonyms=Alpha-2, hLPP1-a, PAP2-a2; IsoId=O14494-2; Sequence=VSP_009651; Note=Ref.2 (AAC16033) sequence is in conflict in positions: 55:V->A, 56:T->A, 69:I->V. {ECO:0000305};
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
CautionPubMed:9305923 states that this phosphatase does not hydrolyze sphingosine 1-phosphate while PubMed:9705349 states that it does. {ECO:0000305}.
Enzyme RegulationInhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.
FunctionBroad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.
InductionBy androgens.
PtmN-glycosylated. Contains high-mannose oligosaccharides.
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityUbiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
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