MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003619

Record overview

MGPD IDMGP003619
Gene ID8612
SpeciesHomo sapiens (Human)
Gene Namephosphatidic acid phosphatase type 2C
Gene Symbol PPAP2C
SynonymsLPP2; PAP-2c; PAP2-g;
Alternate nameslipid phosphate phosphohydrolase 2; PAP2-gamma; PAP2c; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphatase 2c; phosphatidic acid phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma;
Chromosome19
Map Location19p13
EC Number3.1.3.4
SummaryThe protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PPAP2C

Proteins

lipid phosphate phosphohydrolase 2 isoform 1
Refseq ID:NP_003703
Protein GI:4505977
UniProt ID:O43688
mRNA ID:NM_003712
Length:288
RefSeq Status:
MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLG
TFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQ
FFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS
 
lipid phosphate phosphohydrolase 2 isoform 2
Refseq ID:NP_803545
Protein GI:29171745
UniProt ID:O43688
mRNA ID:NM_177526
Length:232
RefSeq Status:
MAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPAD
VTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCL
KEEELERKPSLSLTLTLGEADHNHYGYPHSSS
 
lipid phosphate phosphohydrolase 2 isoform 3
Refseq ID:NP_808211
Protein GI:29171747
UniProt ID:O43688
mRNA ID:NM_177543
Length:309
RefSeq Status:
MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLGASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYT
DRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFL
ALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHN
HYGYPHSSS
 
  logo