MGP Database

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MGP003619

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2C
Protein EntryLPP2_HUMAN
UniProt IDO43688
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O43688-1; Sequence=Displayed; Name=2; IsoId=O43688-2; Sequence=VSP_037765; Note=No experimental confirmation available.; Name=3; IsoId=O43688-3; Sequence=VSP_047366; Note=Gene prediction based on EST data.;
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Enzyme RegulationInhibited by sphingosine, zinc ions and propanolol.
FunctionCatalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityFound mainly in brain, pancreas and placenta.
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