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MGP003620

Record overview

MGPD IDMGP003620
Gene ID8613
SpeciesHomo sapiens (Human)
Gene Namephosphatidic acid phosphatase type 2B
Gene Symbol PPAP2B
SynonymsLPP3; VCIP; Dri42; PAP2B;
Alternate nameslipid phosphate phosphohydrolase 3; PAP2 beta; phosphatidate phosphohydrolase type 2b; type-2 phosphatidic acid phosphatase-beta; vascular endothelial growth factor and type I collagen inducible;
Chromosome1
Map Location1p32.2
EC Number3.1.3.4
SummaryThe protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for PPAP2B

Proteins

lipid phosphate phosphohydrolase 3
Refseq ID:NP_003704
Protein GI:29171740
UniProt ID:O14495
mRNA ID:NM_003713
Length:311
RefSeq Status:
MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAI
ITGEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHA
SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVD
IIDRNNHHNMM
 
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