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MGP003623

Record overview

MGPD IDMGP003623
Gene ID8630
SpeciesHomo sapiens (Human)
Gene Namehydroxysteroid (17-beta) dehydrogenase 6
Gene Symbol HSD17B6
SynonymsHSE; RODH; SDR9C6;
Alternate names17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD 6; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; 3-hydroxysteroid epimerase; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; short chain dehydrogenase/reductase family 9C, member 6;
Chromosome12
Map Location12q13
EC Number1.1.1.105
SummaryThe protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for HSD17B6

Proteins

17-beta-hydroxysteroid dehydrogenase type 6 precursor
Refseq ID:NP_003716
Protein GI:19743808
UniProt ID:O14756
mRNA ID:NM_003725
Length:317
RefSeq Status:
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEH
VGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVK
ISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV
 
sig_peptide: 1..17
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (O14756.1)
calculated_mol_wt: 2160
peptide sequence: 
MWLYLAAFVGLYYLLHW

mat_peptide: 18..317
product: 17-beta-hydroxysteroid dehydrogenase type 6
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O14756.1)
calculated_mol_wt: 33824
peptide sequence: 
YRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILT
PITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMT
QSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV
 
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