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MGP003632

Record overview

MGPD IDMGP003632
Gene ID8651
SpeciesHomo sapiens (Human)
Gene Namesuppressor of cytokine signaling 1
Gene Symbol SOCS1
SynonymsJAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1;
Alternate namessuppressor of cytokine signaling 1; JAK binding protein; JAK-binding protein; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; TIP-3; Tec-interacting protein 3; cytokine-inducible SH2 protein 1;
Chromosome16
Map Location16p13.13
SummaryThis gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOCS1

Proteins

suppressor of cytokine signaling 1
Refseq ID:NP_003736
Protein GI:4507233
UniProt ID:O15524
mRNA ID:NM_003745
Length:211
RefSeq Status:
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGT
FLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVL
RDYLSSFPFQI
 
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