MGP Database

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MGP003632

Ontology/Pathway Information

Entrez Gene ID8651
Gene Namesuppressor of cytokine signaling 1
Gene Symbol SOCS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0016023 IEA:UniProtKB-SubCellCcytoplasmic membrane-bounded vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005159 IPI:UniProtKBFinsulin-like growth factor receptor binding
GO:0019210 ISS:UniProtKBFkinase inhibitor activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004860 TAS:ProtIncFprotein kinase inhibitor activity
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0019221 ISS:UniProtKBPcytokine-mediated signaling pathway
GO:0045444 IEA:EnsemblPfat cell differentiation
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0007259 TAS:ProtIncPJAK-STAT cascade
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0046627 ISS:UniProtKBPnegative regulation of insulin receptor signaling pathway
GO:0046426 ISS:UniProtKBPnegative regulation of JAK-STAT cascade
GO:0006469 TAS:GOCPnegative regulation of protein kinase activity
GO:0042518 ISS:UniProtKBPnegative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567 IEA:UniProtKB-UniPathwayPprotein ubiquitination
GO:0040008 IEA:UniProtKB-KWPregulation of growth
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0001932 ISS:UniProtKBPregulation of protein phosphorylation
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75790Cytokine Signaling in Immune system
REACT_111133Growth hormone receptor signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_111225Regulation of KIT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
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