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MGP003648

UniProt Annotations

Entry Information
Gene Namebeclin 1, autophagy related
Protein EntryBECN1_HUMAN
UniProt IDQ14457
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:9765397}.
InteractionQ9C0C7:AMBRA1; NbExp=8; IntAct=EBI-949378, EBI-2512975; Q6ZNE5:ATG14; NbExp=11; IntAct=EBI-949378, EBI-2690371; P10415:BCL2; NbExp=16; IntAct=EBI-949378, EBI-77694; Q07817-1:BCL2L1; NbExp=4; IntAct=EBI-949378, EBI-287195; O15392:BIRC5; NbExp=3; IntAct=EBI-949378, EBI-518823; P53355:DAPK1; NbExp=4; IntAct=EBI-949378, EBI-358616; P00533:EGFR; NbExp=7; IntAct=EBI-949378, EBI-297353; Q8IYI6:EXOC8; NbExp=4; IntAct=EBI-949378, EBI-742102; Q07820:MCL1; NbExp=2; IntAct=EBI-949378, EBI-1003422; Q8NEB9:PIK3C3; NbExp=14; IntAct=EBI-949378, EBI-1056470; Q9NYJ8:TAB2; NbExp=11; IntAct=EBI-949378, EBI-358708; Q8N5C8:TAB3; NbExp=9; IntAct=EBI-949378, EBI-359964; Q9P2Y5:UVRAG; NbExp=15; IntAct=EBI-949378, EBI-2952704; P89884:v-bcl-2 (xeno); NbExp=2; IntAct=EBI-949378, EBI-8849581; A8K0Z3:WASH1; NbExp=3; IntAct=EBI-949378, EBI-6160405; O95229:ZWINT; NbExp=6; IntAct=EBI-949378, EBI-1001132;
PtmPhosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. {ECO:0000269|PubMed:19180116}.
Ptmpolyubiquitinated by NEDD4, both with 'Lys11'- and 'Lys63'- linkages. 'Lys'-11-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes. {ECO:0000269|PubMed:21936852, ECO:0000269|PubMed:21962518}.
SimilarityBelongs to the beclin family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250}.
SubunitInteracts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB (By similarity). Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1. {ECO:0000250, ECO:0000269|PubMed:17337444, ECO:0000269|PubMed:17659302, ECO:0000269|PubMed:17724469, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19180116, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22205736, ECO:0000269|PubMed:9765397}.
Tissue SpecificityUbiquitous.
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