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MGP003653

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 1
Protein EntryDGAT1_HUMAN
UniProt IDO75907
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=25.9 uM for retinol {ECO:0000269|PubMed:16214399}; KM=13.9 uM for palmitoyl coenzyme A {ECO:0000269|PubMed:16214399};
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. {ECO:0000269|PubMed:16214399}.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester. {ECO:0000269|PubMed:16214399}.
DiseaseDiarrhea 7 (DIAR7) [MIM:615863]: A life-threatening disease characterized by severe, intractable, watery diarrhea. {ECO:0000269|PubMed:23114594}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Enzyme RegulationXP620 is a selective DGAT1 inhibitor. {ECO:0000269|PubMed:16214399}.
FunctionCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:9756920}.
InteractionQ99IB8:- (xeno); NbExp=2; IntAct=EBI-3906527, EBI-6927873;
PathwayLipid metabolism; glycerolipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHomodimer or homotetramer. {ECO:0000250}.
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