MGP Database

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MGP003691

Ontology/Pathway Information

Entrez Gene ID8795
Gene Nametumor necrosis factor receptor superfamily, member 10b
Gene Symbol TNFRSF10B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016021 IC:UniProtKBCintegral component of membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004872 NAS:UniProtKBFreceptor activity
GO:0045569 NAS:UniProtKBFTRAIL binding
GO:0006919 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007250 NAS:UniProtKBPactivation of NF-kappaB-inducing kinase activity
GO:0006915 NAS:UniProtKBPapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0007166 TAS:ProtIncPcell surface receptor signaling pathway
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0008625 NAS:UniProtKBPextrinsic apoptotic signaling pathway via death domain receptors
GO:0070059 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042981 NAS:UniProtKBPregulation of apoptotic process
GO:2001239 TAS:ReactomePregulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_1503Caspase-8 activation by cleavage
REACT_1619Death Receptor Signalling
REACT_832Dimerization of procaspase-8
REACT_1059Extrinsic Pathway
REACT_268456Programmed Cell Death
REACT_164011Regulation by c-FLIP
REACT_402TRAIL signaling
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